Yiu AP, Mercaldo V, Yan C, Richards BA, Rashid AJ, Hsiang HL, Pressey J, Mahadevan V, Tran MM, Kushner SA, Woodin MA, Frankland PW and Josselyn SA, “Neurons are recruited to a memory trace based on relative neuronal excitability at the time of training”, Neuron, 83(3), 722-735

Muldal AM, Lillicrap TP, Richards BA and Akerman CJ, “Clonal relationships impact neuronal tuning within a phylogenetically ancient vertebrate brain structure”, Current Biology, 24(16), 1929-1933
June 24, 2015
Multiple memory systems for enhanced reinforcement learning
June 24, 2015
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Yiu AP, Mercaldo V, Yan C, Richards BA, Rashid AJ, Hsiang HL, Pressey J, Mahadevan V, Tran MM, Kushner SA, Woodin MA, Frankland PW and Josselyn SA, “Neurons are recruited to a memory trace based on relative neuronal excitability at the time of training”, Neuron, 83(3), 722-735

Memories are thought to be sparsely encoded in neuronal networks, but little is known about why a given neuron is recruited or allocated to a particular memory trace. Previous research shows that in the lateral amygdala (LA), neurons with increased CREB are selectively recruited to a fear memory trace. CREB is a ubiquitous transcription factor implicated in many cellular processes. Which process mediates neuronal memory allocation? One hypothesis is that CREB increases neuronal excitability to bias neuronal recruitment, although this has not been shown experimentally. Here we use several methods to increase neuronal excitability and show this both biases recruitment into the memory trace and enhances memory formation. Moreover, artificial activation of these neurons alone is a sufficient retrieval cue for fear memory expression, showing that these neurons are critical components of the memory trace. These results indicate that neuronal memory allocation is based on relative neuronal excitability immediately before training.

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