June 24, 2015

Sekeres MJ, Mercaldo V, Richards BA, Sargin D, Mahadevan V, Woodin MA, Frankland PW and Josselyn SA, “Increasing CRTC1 function in the dentate gyrus during memory formation or reactivation increases memory strength without compromising memory quality”, The Journal of Neuroscience, 32(49), 17857-17868

Memory stabilization following encoding (synaptic consolidation) or memory reactivation (reconsolidation) requires gene expression and protein synthesis (Dudai and Eisenberg, 2004; Tronson and Taylor, 2007; Nader and Einarsson, 2010; Alberini, 2011). Although consolidation and reconsolidation may be mediated by distinct molecular mechanisms (Lee et al., 2004), disrupting the function of the transcription factor CREB impairs both processes (Kida et al., 2002; Mamiya et al., 2009). Phosphorylation of CREB at Ser133 recruits CREB binding protein (CBP)/p300 coactivators to activate transcription (Chrivia et al., 1993; Parker et al., 1996). In addition to this well known mechanism, CREB regulated transcription coactivators (CRTCs), previously called […]
June 24, 2015

Richards BA, van Rheede JJ and Akerman CJ, “Visuospatial information in the retinotectal system of xenopus before correct image formation by the developing eye”, Developmental Neurobiology, 72(4), 507-519

The retinotectal pathway of Xenopus laevis is a well-established experimental model for studying activity-dependent processes during visual system development. Such processes can be guided by stimulus-evoked activity patterns, which depend on the refractive characteristics of the eye. Previous work has shown that many animals are hyperopic at early developmental stages due to immature refractive properties. Whether this is also the case for Xenopus laevis is unknown. Here, we measure the focal length of the lens and the size of the eye of embryos at different stages and find that Xenopus laevis exhibits a similar shift from hyperopia to emmetropia. At […]