Richards BA, Aizenman CD and Akerman CJ, “In vivo spike-timing-dependent plasticity in the optic tectum of Xenopus laevis”, Frontiers in Synaptic Neuroscience, 2, 7

Richards BA, Voss OP and Akerman CJ, “GABAergic circuits control stimulus-instructed receptive field development in the optic tectum”, Nature Neuroscience, 13(9), 1098-1106
June 24, 2015
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Richards BA, Aizenman CD and Akerman CJ, “In vivo spike-timing-dependent plasticity in the optic tectum of Xenopus laevis”, Frontiers in Synaptic Neuroscience, 2, 7

Spike-timing-dependent plasticity (STDP) is found in vivo in a variety of systems and species, but the first demonstrations of in vivo STDP were carried out in the optic tectum of Xenopus laevis embryos. Since then, the optic tectum has served as an excellent experimental model for studying STDP in sensory systems, allowing researchers to probe the developmental consequences of this form of synaptic plasticity during early development. In this review, we will describe what is known about the role of STDP in shaping feed-forward and recurrent circuits in the optic tectum with a focus on the functional implications for vision. We will discuss both the similarities and differences between the optic tectum and mammalian sensory systems that are relevant to STDP. Finally, we will highlight the unique properties of the embryonic tectum that make it an important system for researchers who are interested in how STDP contributes to activity-dependent development of sensory computations.

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