June 24, 2015

Richards BA, Aizenman CD and Akerman CJ, “In vivo spike-timing-dependent plasticity in the optic tectum of Xenopus laevis”, Frontiers in Synaptic Neuroscience, 2, 7

Spike-timing-dependent plasticity (STDP) is found in vivo in a variety of systems and species, but the first demonstrations of in vivo STDP were carried out in the optic tectum of Xenopus laevis embryos. Since then, the optic tectum has served as an excellent experimental model for studying STDP in sensory systems, allowing researchers to probe the developmental consequences of this form of synaptic plasticity during early development. In this review, we will describe what is known about the role of STDP in shaping feed-forward and recurrent circuits in the optic tectum with a focus on the functional implications for vision. […]